NittoPhase™ HL

NittoPhase™ HL

Since its introduction in 2004, the NittoPhase™ product line has established itself as a leading solid support for therapeutic oligonucleotide synthesis, with proven performance in commerical production at scales up to 400 mmol. Building on this foundation, NittoPhase™ HL extends the platform with a high-loading solid support that pushes the limits of solid-phase oligonucleotide synthesis.

The exceptional loading capacity of NittoPhase™ HL enables higher synthesis scales per column volume while maintaining the superior yields and full-length purity associated with the NittoPhase™ platform. This efficiency and meaningful reductions in overall synthesis cost— without compromise.

Product Features

Revolutionary New Support with Loading Capacity up to 400 µmol/g for DNA & RNA Synthesis

High Loading Capacity

Novel design enables higher loading capacity level for solid support, resulting in potentially unprecedented synthesis yields.

Reduce Oligonucleotide Synthesis Costs

High loading allows greater synthesis scale per column volume, delivering outstanding synthesis cost savings.

Superior Flexibility

Synthesize RNA, longmers and other modified molecules at higher loadings than ever before.

Proven Performance

Performance has been thoroughly tested, showing consistently high yields and improved purity profiles across a range of sequences.

Highest Quality

NittoPhase™ HL products are manufactured under ISO 9001:2015 guidelines. Kinovate provides you with all the documents you need to file with regulatory agencies.

NittoPhase™ HL Technical Info

Access technical documentation and resources for NittoPhase™ HL, including product specifications, synthesis performance data, and recommended protocols for column packing and laboratory use.


Data Sheet

NittoPhase™ HL solid support data sheet with product descriptions, properties and DNA and RNA synthesis data from lab scale to commercial scale up to 900 mmol.

Technical Paper

A series of lab to commercial synthesis scale data using NittoPhase™ HL solid support. Data display highly favorable DNA synthesis results up to 900 mmol and modified RNA synthesis results up to 65 mmol.

Column Packing Protocol

Column packing recommendations of NittoPhase™ HL solid support for various fixed-bed column sizes and adjustable column

Safety Datasheets

Note: XXX represent the loading capacity of the solid support in µmol/g


NittoPhase™HL 2'Fluoro A(bz) XXX Solid Support

NittoPhase™ HL 2'OMeC XXX Solid Support

NittoPhase™ HL 2'-Fluoro U XXX Solid Support

NittoPhase™ HL 2'-OMeA XXX Solid Support

NittoPhase™ HL 2'-OMeG XXX Solid Support

NittoPhase™ HL 2'-OMeU XXX Solid Support

NittoPhase™ HL AmFmc O C7 XXX Solid Support

NittoPhase™ HL Inverted dA XXX Solid Support

NittoPhase™ HL Inverted T XXX Solid Support

NittoPhase™ HL Pi XXX Solid Support

NittoPhase™ HL rA XXX Solid Support

NittoPhase™ HL rC XXX Solid Support

NittoPhase™ HL rG XXX Solid Support

NittoPhase™ HL rU XXX Solid Support

NittoPhase™ HL T XXX Solid Support

NittoPhase™ HL UnyLinker™ XXX Solid Support

NittoPhase™ HL Reverse Abasic XXX Solid Support

NittoPhase™ HL C6-Phthalamido XXX Solid Support

Product Ordering

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