NittoPhase™ SL

NittoPhase™ SL

Now available, the NittoPhase™ SL has arrived to usher in the next generation of solid support for short-mer and ligation workflows. With higher loading and higher yield than ever before, NittoPhase™ SL allows for 650 umol/g linker loading density and produces higher yields than previous entries in the NittoPhase™ product family.

Highly optimized for short-mer synthesis and built to scale, NittoPhase™ SL has shown itself to be conducive towards reduction in total cost of API manufacturing via Ligation. Contact us today to get more information about this exciting new product.

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Higher Loading, Higher Yield

Scalable across increased packing densities, and applicable for short-mer and enzymatic ligation technology.
Up to 650 umol/g linker loading density
Up to 2x higher yields over current NittoPhase™ HL
Highly optimized for short-mer synthesis and enzymatic ligation
Demonstrated scalability across increased column packing densities
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NPHL vs. NPSL

Yield and Crude Purity Across Loading and Column Packing Density

Conditions: Inclisiran Antisense 10-mer | ÄKTA OligoPilot™ 100 | 25.1 mL Column*

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  • (A) NPHL 354 µmol/g 0.109 g/mL (Control)
  • (B) NPSL 547 µmol/g 0.109 g/mL
  • (C) NPSL 561 µmol/g 0.109 g/mL
  • (D) NPSL 547 µmol/g 0.120 g/mL
  • (E) NPSL 620 µmol/g 0.120 g/mL
  • (F) NPSL 600 µmol/g 0.130 g/mL
Condition 2^OMeA(bz) Loading Density (µmol/g) Column Packing Density (g/mL) Crude Purity (%) OD260 Yield (Total / FLP) Yield vs NPHL (Total / FLP)
NPHL (Control) 354 0.109 93.2 89,523 / 83,431 1.00x / 1.00x
NPSL 547 0.109 91.9 138,964 / 127,666 1.55x / 1.53x
561 0.109 92.5 141,535 / 130,920 1.58x / 1.57x
547 0.12 93.2 153,132 / 142,701 1.71x / 1.71x
620 0.12 92.8 173,254 / 160,844 1.94x / 1.93x
600 0.13 91.9 186,265 / 171,214 2.08x / 2.05x

*Yield benchmark is based on Inclisiran Antisense 10-mer synthesis using 2^OMeA(bz) loaded supports and is relative to NPHL loaded at 350 umol/g under comparable synthesis and analytical conditions. Actual yield performance may vary by application and depends on ligand loading clarity, ligand molecular weight and proper conditions.

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