NittoPhase®

Product Desciption
NittoPhase® solid support utilizes state-of-the-art polymer synthesis capabilities to provide a solid support for therapeutic oligonucleotide synthesis offering the highest available performance at a greatly reduced cost. The superior properties of Nitto’s proprietary formulated cross-linked polystyrene structure deliver increased yields with greater purity at lower unit cost. NittoPhase® thus delivers a positive impact on both the overall cost and quality of both small and large scale oligonucleotide synthesis.

Features

• Superior synthesis yield
• High loading capacity
• Exceptional full length purity
• Lower back-pressure
• Cost effective
• Secure manufacturing and supply
• Custom load capable
• Suitable for packed-bed synthesizers such as ÄKTA Oligopilot™ & OligoProcess™

Properties
NittoPhase® is available as a fully derivatized support, loaded to customer specifications.

• Polymer Matrix - Cross linked polystyrene
• Functionality - Hydroxyl group
• Average Particle Size - 90 μm
• Average Pore Size - 55nm
• Dry Volume - 2.95 ml/g
• Optimal Loading - 200 μmol/g
• Swelling Volume (in acteonitrile) - 4.0 ml/g
• Swelling Volume (in toluene) - 6.4 ml/g

Capabilities
Nitto Denko Corporation and its subsidiary Nitto Denko Technical Corporation, a dedicated research and development facility in Oceanside, California, has applied its unparalleled polymer synthesis expertise to create a solid support product that will deliver higher performance at a lower cost to users. Nitto’s in- house manufacturing and nucleoside loading facilities have the capability to produce supports from laboratory to commercial scale, tailored precisely to customer requirements.